Assay Detail
Toxicity
CHEMBL5161849
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Cytotoxicity against human THLE-2 cell assessed as inhibition of cell growth after 24 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | THLE-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.84 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL252370 | — | — | 1 | 8.30 |
| CHEMBL5204031 | — | — | 1 | 5.55 |
| CHEMBL5205337 | — | — | 1 | 5.24 |
| CHEMBL5176126 | — | — | 1 | 5.15 |
| CHEMBL5204410 | — | — | 1 | 4.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL252370 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5204031 | — | IC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL5205337 | — | IC50 | = | 5720.0 | nM | 5.24 |
| CHEMBL5176126 | — | IC50 | = | 7150.0 | nM | 5.15 |
| CHEMBL5204410 | — | IC50 | = | 10600.0 | nM | 4.97 |