Assay Detail
Toxicity
CHEMBL5161850
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Cytotoxicity against human BEAS-2B cell assessed as inhibition of cell growth after 24 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | BEAS-2B |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.51 | 7.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL252370 | — | — | 1 | 7.18 |
| CHEMBL5205337 | — | — | 1 | 5.00 |
| CHEMBL5204031 | — | — | 1 | 4.93 |
| CHEMBL5204410 | — | — | 1 | 4.91 |
| CHEMBL5176126 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL252370 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL5205337 | — | IC50 | = | 10030.0 | nM | 5.00 |
| CHEMBL5204031 | — | IC50 | = | 11610.0 | nM | 4.93 |
| CHEMBL5204410 | — | IC50 | = | 12180.0 | nM | 4.91 |
| CHEMBL5176126 | — | IC50 | > | 50000.0 | nM | - |