Assay Detail
Binding
CHEMBL5162239
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hrs by QUANTI Luc based microplate reader method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | THP1-Dual |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Stimulator of interferon genes protein (CHEMBL4523377) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of Potent Immune Modulators Targeting Stimulator of Interferon Genes Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 5.47 | 9.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5201766 | — | — | 1 | 9.45 |
| CHEMBL5174660 | — | — | 1 | 8.79 |
| CHEMBL4793625 | — | — | 1 | 6.09 |
| CHEMBL4440744 | — | — | 1 | 5.91 |
| CHEMBL5169574 | — | — | 1 | 5.78 |
| CHEMBL5187032 | — | — | 1 | 5.77 |
| CHEMBL5194415 | — | — | 1 | 5.34 |
| CHEMBL5176115 | — | — | 1 | 5.21 |
| CHEMBL5205725 | — | — | 1 | 5.18 |
| CHEMBL5205871 | — | — | 1 | 5.04 |
| CHEMBL5197505 | — | — | 1 | 4.75 |
| CHEMBL5199858 | — | — | 1 | 4.54 |
| CHEMBL5173411 | — | — | 1 | 4.53 |
| CHEMBL5185786 | — | — | 1 | 4.52 |
| CHEMBL4465054 | — | — | 1 | 4.52 |
| CHEMBL5192829 | — | — | 1 | 4.41 |
| CHEMBL5200249 | — | — | 1 | 4.31 |
| CHEMBL5196300 | — | — | 1 | 4.29 |
| CHEMBL4522871 | — | — | 1 | - |
| CHEMBL5187131 | — | — | 1 | - |
| CHEMBL4438309 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5201766 | — | EC50 | = | 0.3536 | nM | 9.45 |
| CHEMBL5174660 | — | EC50 | = | 1.624 | nM | 8.79 |
| CHEMBL4793625 | — | EC50 | = | 803.8 | nM | 6.09 |
| CHEMBL4440744 | — | EC50 | = | 1232.0 | nM | 5.91 |
| CHEMBL5169574 | — | EC50 | = | 1661.0 | nM | 5.78 |
| CHEMBL5187032 | — | EC50 | = | 1689.0 | nM | 5.77 |
| CHEMBL5194415 | — | EC50 | = | 4597.0 | nM | 5.34 |
| CHEMBL5176115 | — | EC50 | = | 6222.0 | nM | 5.21 |
| CHEMBL5205725 | — | EC50 | = | 6546.0 | nM | 5.18 |
| CHEMBL5205871 | — | EC50 | = | 9116.0 | nM | 5.04 |
| CHEMBL5197505 | — | EC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL5199858 | — | EC50 | = | 28640.0 | nM | 4.54 |
| CHEMBL5173411 | — | EC50 | = | 29830.0 | nM | 4.53 |
| CHEMBL5185786 | — | EC50 | = | 30060.0 | nM | 4.52 |
| CHEMBL4465054 | — | EC50 | = | 30100.0 | nM | 4.52 |
| CHEMBL5192829 | — | EC50 | = | 39130.0 | nM | 4.41 |
| CHEMBL5200249 | — | EC50 | = | 48580.0 | nM | 4.31 |
| CHEMBL5196300 | — | EC50 | = | 51070.0 | nM | 4.29 |
| CHEMBL4522871 | — | EC50 | = | 102000.0 | nM | - |
| CHEMBL5187131 | — | EC50 | = | 0.004028 | nM | - |
| CHEMBL4438309 | — | EC50 | < | 1.0 | nM | - |