Assay Detail
Functional
CHEMBL5162305
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Antiproliferative activity against human NCI-N87 cells assessed as inhibition of cell growth incubated for 72 hrs by Celltiter-Glo assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-N87 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of SPH5030, a Selective, Potent, and Irreversible Tyrosine Kinase Inhibitor for HER2-Amplified and HER2-Mutant Cancer Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 8.23 | 9.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5181694 | — | — | 1 | 9.25 |
| CHEMBL180022 | NERATINIB | 4.0 | 1 | 9.19 |
| CHEMBL3647420 | PYROTINIB | 3.0 | 1 | 9.07 |
| CHEMBL5170965 | — | — | 1 | 8.97 |
| CHEMBL5178703 | — | — | 1 | 8.96 |
| CHEMBL5184610 | — | — | 1 | 8.95 |
| CHEMBL5176854 | — | — | 1 | 8.81 |
| CHEMBL5190132 | — | — | 1 | 8.72 |
| CHEMBL5179954 | — | — | 1 | 8.66 |
| CHEMBL5193451 | — | — | 1 | 8.58 |
| CHEMBL5201973 | — | — | 1 | 8.39 |
| CHEMBL5192750 | — | — | 1 | 8.34 |
| CHEMBL5183924 | — | — | 1 | 8.18 |
| CHEMBL5209046 | — | — | 1 | 8.17 |
| CHEMBL5175873 | — | — | 1 | 7.93 |
| CHEMBL5180725 | — | — | 1 | 7.72 |
| CHEMBL5202846 | — | — | 1 | 7.55 |
| CHEMBL5180965 | — | — | 1 | 7.48 |
| CHEMBL5176920 | — | — | 1 | 7.38 |
| CHEMBL5175489 | — | — | 1 | 7.29 |
| CHEMBL5203179 | — | — | 1 | 7.09 |
| CHEMBL5200783 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5181694 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL180022 | NERATINIB | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL3647420 | PYROTINIB | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL5170965 | — | IC50 | = | 1.08 | nM | 8.97 |
| CHEMBL5178703 | — | IC50 | = | 1.09 | nM | 8.96 |
| CHEMBL5184610 | — | IC50 | = | 1.12 | nM | 8.95 |
| CHEMBL5176854 | — | IC50 | = | 1.55 | nM | 8.81 |
| CHEMBL5190132 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5179954 | — | IC50 | = | 2.17 | nM | 8.66 |
| CHEMBL5193451 | — | IC50 | = | 2.65 | nM | 8.58 |
| CHEMBL5201973 | — | IC50 | = | 4.08 | nM | 8.39 |
| CHEMBL5192750 | — | IC50 | = | 4.55 | nM | 8.34 |
| CHEMBL5183924 | — | IC50 | = | 6.56 | nM | 8.18 |
| CHEMBL5209046 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL5175873 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL5180725 | — | IC50 | = | 19.19 | nM | 7.72 |
| CHEMBL5202846 | — | IC50 | = | 28.28 | nM | 7.55 |
| CHEMBL5180965 | — | IC50 | = | 32.89 | nM | 7.48 |
| CHEMBL5176920 | — | IC50 | = | 41.7 | nM | 7.38 |
| CHEMBL5175489 | — | IC50 | = | 51.9 | nM | 7.29 |
| CHEMBL5203179 | — | IC50 | = | 80.74 | nM | 7.09 |
| CHEMBL5200783 | — | IC50 | = | 441.2 | nM | 6.36 |