Assay Detail
Functional
CHEMBL5162911
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition measured upto 4 hrs by CellTiter-Blue cell viability assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 2H-Imidazo[2',1':2,3] [1,3]thiazolo[4,5-e]isoindol-8-yl-phenylureas with promising therapeutic features for the treatment of acute myeloid leukemia (AML) with FLT3/ITD mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.29 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5183674 | — | — | 1 | 6.22 |
| CHEMBL522892 | DOVITINIB | 3.0 | 1 | 6.04 |
| CHEMBL5185748 | — | — | 1 | 5.88 |
| CHEMBL5189185 | — | — | 1 | 5.84 |
| CHEMBL5173972 | — | — | 1 | 5.84 |
| CHEMBL5184524 | — | — | 1 | 5.78 |
| CHEMBL5206333 | — | — | 1 | 5.75 |
| CHEMBL5190625 | — | — | 1 | 5.58 |
| CHEMBL5198100 | — | — | 1 | 5.55 |
| CHEMBL5205434 | — | — | 1 | 5.39 |
| CHEMBL5199887 | — | — | 1 | 5.38 |
| CHEMBL5209513 | — | — | 1 | 5.38 |
| CHEMBL5177051 | — | — | 1 | 5.37 |
| CHEMBL5169362 | — | — | 1 | 5.37 |
| CHEMBL5188083 | — | — | 1 | 5.33 |
| CHEMBL5176979 | — | — | 1 | 4.86 |
| CHEMBL5207705 | — | — | 1 | 4.84 |
| CHEMBL5205101 | — | — | 1 | 4.70 |
| CHEMBL5207842 | — | — | 1 | 4.56 |
| CHEMBL5207335 | — | — | 1 | 4.43 |
| CHEMBL5202676 | — | — | 1 | 4.21 |
| CHEMBL5177337 | — | — | 1 | 4.00 |
| CHEMBL210833 | — | — | 1 | - |
| CHEMBL576982 | QUIZARTINIB | 4.0 | 1 | - |
| CHEMBL5173318 | — | — | 1 | - |
| CHEMBL5173261 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5183674 | — | IC50 | = | 608.0 | nM | 6.22 |
| CHEMBL522892 | DOVITINIB | IC50 | = | 911.0 | nM | 6.04 |
| CHEMBL5185748 | — | IC50 | = | 1318.0 | nM | 5.88 |
| CHEMBL5189185 | — | IC50 | = | 1437.0 | nM | 5.84 |
| CHEMBL5173972 | — | IC50 | = | 1432.0 | nM | 5.84 |
| CHEMBL5184524 | — | IC50 | = | 1672.0 | nM | 5.78 |
| CHEMBL5206333 | — | IC50 | = | 1761.0 | nM | 5.75 |
| CHEMBL5190625 | — | IC50 | = | 2624.0 | nM | 5.58 |
| CHEMBL5198100 | — | IC50 | = | 2818.0 | nM | 5.55 |
| CHEMBL5205434 | — | IC50 | = | 4063.0 | nM | 5.39 |
| CHEMBL5199887 | — | IC50 | = | 4173.0 | nM | 5.38 |
| CHEMBL5209513 | — | IC50 | = | 4128.0 | nM | 5.38 |
| CHEMBL5177051 | — | IC50 | = | 4256.0 | nM | 5.37 |
| CHEMBL5169362 | — | IC50 | = | 4306.0 | nM | 5.37 |
| CHEMBL5188083 | — | IC50 | = | 4619.0 | nM | 5.33 |
| CHEMBL5176979 | — | IC50 | = | 13891.0 | nM | 4.86 |
| CHEMBL5207705 | — | IC50 | = | 14450.0 | nM | 4.84 |
| CHEMBL5205101 | — | IC50 | = | 19920.0 | nM | 4.70 |
| CHEMBL5207842 | — | IC50 | = | 27461.0 | nM | 4.56 |
| CHEMBL5207335 | — | IC50 | = | 37010.0 | nM | 4.43 |
| CHEMBL5202676 | — | IC50 | = | 62220.0 | nM | 4.21 |
| CHEMBL5177337 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL210833 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL576982 | QUIZARTINIB | IC50 | > | 100000.0 | nM | - |
| CHEMBL5173318 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5173261 | — | IC50 | > | 100000.0 | nM | - |