Assay Detail
Binding
CHEMBL5162941
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Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and measured for 180 secs by Ellman's spectrophotometric method
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Cerebral cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel inhibitors of AChE and Aβ aggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.65 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5180947 | — | — | 1 | 8.62 |
| CHEMBL5198028 | — | — | 1 | 8.42 |
| CHEMBL5204649 | — | — | 1 | 8.39 |
| CHEMBL5202413 | — | — | 1 | 8.36 |
| CHEMBL5190674 | — | — | 1 | 8.36 |
| CHEMBL5200196 | — | — | 1 | 8.33 |
| CHEMBL5173612 | — | — | 1 | 8.30 |
| CHEMBL5188181 | — | — | 1 | 8.29 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 8.27 |
| CHEMBL5206971 | — | — | 1 | 8.26 |
| CHEMBL5204001 | — | — | 1 | 8.15 |
| CHEMBL5199752 | — | — | 1 | 8.07 |
| CHEMBL5187084 | — | — | 1 | 7.96 |
| CHEMBL5186127 | — | — | 1 | 7.95 |
| CHEMBL5201084 | — | — | 1 | 7.95 |
| CHEMBL5174806 | — | — | 1 | 7.94 |
| CHEMBL5182685 | — | — | 1 | 7.94 |
| CHEMBL5179256 | — | — | 1 | 7.92 |
| CHEMBL5205085 | — | — | 1 | 7.89 |
| CHEMBL5174088 | — | — | 1 | 7.83 |
| CHEMBL5209880 | — | — | 1 | 7.17 |
| CHEMBL5169530 | — | — | 1 | 6.89 |
| CHEMBL5190328 | — | — | 1 | 6.50 |
| CHEMBL5208030 | — | — | 1 | 6.47 |
| CHEMBL5197334 | — | — | 1 | 5.74 |
| CHEMBL5193449 | — | — | 1 | 5.52 |
| CHEMBL5173396 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5180947 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5198028 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL5204649 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL5202413 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL5190674 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL5200196 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL5173612 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5188181 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL5206971 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL5204001 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL5199752 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL5187084 | — | IC50 | = | 11.1 | nM | 7.96 |
| CHEMBL5186127 | — | IC50 | = | 11.3 | nM | 7.95 |
| CHEMBL5201084 | — | IC50 | = | 11.3 | nM | 7.95 |
| CHEMBL5174806 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL5182685 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL5179256 | — | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL5205085 | — | IC50 | = | 12.9 | nM | 7.89 |
| CHEMBL5174088 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL5209880 | — | IC50 | = | 67.6 | nM | 7.17 |
| CHEMBL5169530 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL5190328 | — | IC50 | = | 317.0 | nM | 6.50 |
| CHEMBL5208030 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5197334 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL5193449 | — | IC50 | = | 3007.0 | nM | 5.52 |
| CHEMBL5173396 | — | IC50 | = | 8437.0 | nM | 5.07 |