Assay Detail

CHEMBL5163367

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiviral activity against MERS-CoV infected in Vero E6 cells expressing human transmembrane protease serine 2 assessed as inhibition of viral cytopathic effect by measuring cell viability incubated for 3 days by MTT assay

ChEMBL ↗

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Target

Middle East respiratory syndrome-related coronavirus (CHEMBL4296578) ↗

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Middle East respiratory syndrome-related coronavirus (CHEMBL4296578) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Middle East respiratory syndrome-related coronavirus

CHEMBL4296578

Anchored from Assay target.

Protein identity Middle East respiratory syndrome-related coronavirus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Middle East respiratory syndrome-related coronavirus
Cell Type	Vero E6
Confidence	1 — Organism
Curated By	Autocuration

Target

Middle East respiratory syndrome-related coronavirus (CHEMBL4296578) ↗

Type	ORGANISM
Organism	Middle East respiratory syndrome-related coronavirus

Publication

Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19.

Unoh Y, Uehara S, Nakahara K, Nobori H, Yamatsu Y, Yamamoto S, Maruyama Y, Taoda Y, Kasamatsu K, Suto T, Kouki K, Nakahashi A, Kawashima S, Sanaki T, Toba S, Uemura K, Mizutare T, Ando S, Sasaki M, Orba Y, Sawa H, Sato A, Sato T, Kato T, Tachibana Y.
J Med Chem (2022) 65 : 6499 -6512
PubMed 35352927 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	5.85	5.85

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5183847	ENSITRELVIR	3.0	1	5.85

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5183847	ENSITRELVIR	EC50	=	1400.0	nM	5.85