Assay Detail
Binding
CHEMBL5164005
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DPCPX from human A1AR incubated for 60 mins by scintillation counter analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual-acting antitumor agents targeting the A<sub>2A</sub> adenosine receptor and histone deacetylases: Design and synthesis of 4-(furan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.49 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5201523 | — | — | 1 | 6.98 |
| CHEMBL5199428 | — | — | 1 | 6.30 |
| CHEMBL5188801 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5201523 | — | Ki | = | 105.6 | nM | 6.98 |
| CHEMBL5199428 | — | Ki | = | 503.3 | nM | 6.30 |
| CHEMBL5188801 | — | Ki | = | 641.0 | nM | 6.19 |