Assay Detail
Binding
CHEMBL5164048
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Binding affinity to rat sigma 2 receptor/TMEM97 expressed in rat PC-12 cells assessed as inhibition constant
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | PC-12 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma intracellular receptor 2 (CHEMBL4105864) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Preparation of novel analogs of 2-arylpiperidines and evaluation of their sigma receptor binding affinities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.58 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5175530 | — | — | 1 | 8.29 |
| CHEMBL5190189 | — | — | 1 | 7.64 |
| CHEMBL5189158 | — | — | 1 | 7.34 |
| CHEMBL1698776 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5175530 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL5190189 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL5189158 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL1698776 | — | Ki | = | 90.0 | nM | 7.05 |