Assay Detail
Binding
CHEMBL5164049
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to sigma 1 receptor expressed in guinea pig brain membrane assessed as inhibition constant
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL4153) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Preparation of novel analogs of 2-arylpiperidines and evaluation of their sigma receptor binding affinities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.31 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5175530 | — | — | 1 | 6.64 |
| CHEMBL5190189 | — | — | 1 | 6.61 |
| CHEMBL1698776 | — | — | 1 | 6.08 |
| CHEMBL5189158 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5175530 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL5190189 | — | Ki | = | 248.0 | nM | 6.61 |
| CHEMBL1698776 | — | Ki | = | 841.0 | nM | 6.08 |
| CHEMBL5189158 | — | Ki | = | 1279.0 | nM | 5.89 |