Assay Detail
Binding
CHEMBL5164562
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant full length GST-tagged MNK1 expressed in baculovirus expression system using S6 peptide as substrate in presence of [gamma-33P]-ATP incubated for 60 mins by radiometric scintillation counting method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
MAP kinase-interacting serine/threonine-protein kinase 1 (CHEMBL4718) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Overcoming Paradoxical Kinase Priming by a Novel MNK1 Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.81 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5189796 | — | — | 1 | 6.16 |
| CHEMBL5187079 | — | — | 1 | 5.89 |
| CHEMBL1240885 | — | — | 1 | 5.82 |
| CHEMBL5180935 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5189796 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL5187079 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1240885 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL5180935 | — | IC50 | = | 4200.0 | nM | 5.38 |