Assay Detail
Binding
CHEMBL5164639
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Inhibition of MDM2 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.10 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4091801 | ALRIZOMADLIN | 2.0 | 1 | 8.42 |
| CHEMBL5196857 | — | — | 1 | 8.22 |
| CHEMBL5206050 | — | — | 1 | 8.05 |
| CHEMBL2402573 | — | — | 1 | 8.05 |
| CHEMBL2386346 | RO-5045337 | 1.0 | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4091801 | ALRIZOMADLIN | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL5196857 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5206050 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2402573 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2386346 | RO-5045337 | IC50 | = | 18.0 | nM | 7.75 |