Assay Detail
Binding
CHEMBL5164736
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Staphylococcus aureus FtsZ assessed as dissociation constant by isothermal titration calorimetry
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of quinolinium-based derivatives targeting FtsZ for antibacterial evaluation and mechanistic study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 5.51 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5188114 | — | — | 1 | 5.62 |
| CHEMBL5200927 | — | — | 1 | 5.60 |
| CHEMBL5174791 | — | — | 1 | 5.42 |
| CHEMBL5186593 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5188114 | — | Kd | = | 2380.0 | nM | 5.62 |
| CHEMBL5200927 | — | Kd | = | 2490.0 | nM | 5.60 |
| CHEMBL5174791 | — | Kd | = | 3840.0 | nM | 5.42 |
| CHEMBL5186593 | — | Kd | = | 3860.0 | nM | 5.41 |