Assay Detail
Binding
CHEMBL5165090
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Binding affinity towards His-tagged recombinant human PD-L1 measured by MicroScale Thermophoresis (MST) assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrazolones as inhibitors of immune checkpoint blocking the PD-1/PD-L1 interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 39 | 6.75 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5207924 | — | — | 1 | 8.92 |
| CHEMBL5194957 | — | — | 1 | 7.72 |
| CHEMBL5176505 | — | — | 1 | 7.64 |
| CHEMBL374252 | — | — | 1 | 7.11 |
| CHEMBL5171729 | — | — | 1 | 7.08 |
| CHEMBL5203947 | — | — | 1 | 6.96 |
| CHEMBL5177267 | — | — | 1 | 6.81 |
| CHEMBL5194902 | — | — | 1 | 6.47 |
| CHEMBL5186432 | — | — | 1 | 6.42 |
| CHEMBL5194707 | — | — | 1 | 6.23 |
| CHEMBL5185402 | — | — | 1 | 5.96 |
| CHEMBL5207258 | — | — | 1 | 5.92 |
| CHEMBL5177805 | — | — | 1 | 4.57 |
| CHEMBL5176662 | — | — | 1 | - |
| CHEMBL5200767 | — | — | 1 | - |
| CHEMBL5195863 | — | — | 1 | - |
| CHEMBL5171793 | — | — | 1 | - |
| CHEMBL5184994 | — | — | 1 | - |
| CHEMBL5191543 | — | — | 1 | - |
| CHEMBL5202632 | — | — | 1 | - |
| CHEMBL5175272 | — | — | 1 | - |
| CHEMBL5198112 | — | — | 1 | - |
| CHEMBL5174242 | — | — | 1 | - |
| CHEMBL5201548 | — | — | 1 | - |
| CHEMBL5194041 | — | — | 1 | - |
| CHEMBL5208834 | — | — | 1 | - |
| CHEMBL5207432 | — | — | 1 | - |
| CHEMBL5207377 | — | — | 1 | - |
| CHEMBL5184739 | — | — | 1 | - |
| CHEMBL5196727 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5207924 | — | Kd | = | 1.19 | nM | 8.92 |
| CHEMBL5194957 | — | Kd | = | 19.0 | nM | 7.72 |
| CHEMBL5176505 | — | Kd | = | 23.0 | nM | 7.64 |
| CHEMBL374252 | — | Kd | = | 77.0 | nM | 7.11 |
| CHEMBL5171729 | — | Kd | = | 83.0 | nM | 7.08 |
| CHEMBL5203947 | — | Kd | = | 110.0 | nM | 6.96 |
| CHEMBL5177267 | — | Kd | = | 156.0 | nM | 6.81 |
| CHEMBL5194902 | — | Kd | = | 340.0 | nM | 6.47 |
| CHEMBL5186432 | — | Kd | = | 385.0 | nM | 6.42 |
| CHEMBL5194707 | — | Kd | = | 584.0 | nM | 6.23 |
| CHEMBL5185402 | — | Kd | = | 1090.0 | nM | 5.96 |
| CHEMBL5207258 | — | Kd | = | 1200.0 | nM | 5.92 |
| CHEMBL5177805 | — | Kd | = | 27000.0 | nM | 4.57 |
| CHEMBL5171793 | — | Kd | > | 500000.0 | nM | - |
| CHEMBL5195863 | — | Kd | - | — | - | |
| CHEMBL5200767 | — | Kd | - | — | - | |
| CHEMBL5176662 | — | Kd | > | 500000.0 | nM | - |
| CHEMBL5181468 | — | Kd | - | — | - | |
| CHEMBL5205700 | — | Kd | - | — | - | |
| CHEMBL5177461 | — | Kd | > | 500000.0 | nM | - |
| CHEMBL5178357 | — | Kd | - | — | - | |
| CHEMBL5176712 | — | Kd | - | — | - | |
| CHEMBL5196389 | — | Kd | > | 500000.0 | nM | - |
| CHEMBL5195841 | — | Kd | > | 500000.0 | nM | - |
| CHEMBL5192546 | — | Kd | - | — | - | |
| CHEMBL5190321 | — | Kd | > | 500000.0 | nM | - |
| CHEMBL5184994 | — | Kd | - | — | - | |
| CHEMBL5191543 | — | Kd | - | — | - | |
| CHEMBL5202632 | — | Kd | - | — | - | |
| CHEMBL5175272 | — | Kd | - | — | - | |
| CHEMBL5198112 | — | Kd | - | — | - | |
| CHEMBL5174242 | — | Kd | - | — | - | |
| CHEMBL5201548 | — | Kd | - | — | - | |
| CHEMBL5194041 | — | Kd | - | — | - | |
| CHEMBL5208834 | — | Kd | > | 500000.0 | nM | - |
| CHEMBL5207432 | — | Kd | > | 500000.0 | nM | - |
| CHEMBL5207377 | — | Kd | > | 500000.0 | nM | - |
| CHEMBL5184739 | — | Kd | > | 500000.0 | nM | - |
| CHEMBL5196727 | — | Kd | > | 500000.0 | nM | - |