Assay Detail
Binding
CHEMBL5165091
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Binding affinity towards His-tagged recombinant human PD-L1 measured by MST dimerization binding assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrazolones as inhibitors of immune checkpoint blocking the PD-1/PD-L1 interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 7.92 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5207924 | — | — | 1 | 9.15 |
| CHEMBL5171729 | — | — | 1 | 8.70 |
| CHEMBL5194957 | — | — | 1 | 7.62 |
| CHEMBL4089730 | — | — | 1 | 7.43 |
| CHEMBL5176505 | — | — | 1 | 7.34 |
| CHEMBL374252 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5207924 | — | Kd | = | 0.7 | nM | 9.15 |
| CHEMBL5171729 | — | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL5194957 | — | Kd | = | 24.0 | nM | 7.62 |
| CHEMBL4089730 | — | Kd | = | 37.0 | nM | 7.43 |
| CHEMBL5176505 | — | Kd | = | 46.0 | nM | 7.34 |
| CHEMBL374252 | — | Kd | = | 53.0 | nM | 7.28 |