Assay Detail
Functional
CHEMBL5165222
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human NCI-H1581 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1581 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and promising anti-tumor efficacy of novel imidazo[1,2-a]pyridine derivatives as potent autotaxin allosteric inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.32 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5171446 | — | — | 1 | 5.39 |
| CHEMBL5177541 | — | — | 1 | 5.32 |
| CHEMBL5189914 | — | — | 1 | 5.32 |
| CHEMBL5179219 | — | — | 1 | 5.25 |
| CHEMBL5171136 | — | — | 1 | - |
| CHEMBL5170680 | — | — | 1 | - |
| CHEMBL5195787 | — | — | 1 | - |
| CHEMBL5189398 | — | — | 1 | - |
| CHEMBL3828074 | ZIRITAXESTAT | 3.0 | 1 | - |
| CHEMBL3186509 | — | — | 1 | - |
| CHEMBL5194357 | — | — | 1 | - |
| CHEMBL5179154 | — | — | 1 | - |
| CHEMBL5190828 | — | — | 1 | - |
| CHEMBL5174427 | — | — | 1 | - |
| CHEMBL5194595 | — | — | 1 | - |
| CHEMBL5204526 | — | — | 1 | - |
| CHEMBL5200527 | — | — | 1 | - |
| CHEMBL5204000 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5171446 | — | IC50 | = | 4040.0 | nM | 5.39 |
| CHEMBL5177541 | — | IC50 | = | 4760.0 | nM | 5.32 |
| CHEMBL5189914 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL5179219 | — | IC50 | = | 5670.0 | nM | 5.25 |
| CHEMBL5171136 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5170680 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5195787 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5189398 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3828074 | ZIRITAXESTAT | IC50 | > | 20000.0 | nM | - |
| CHEMBL3186509 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5194357 | — | IC50 | - | — | - | |
| CHEMBL5179154 | — | IC50 | - | — | - | |
| CHEMBL5190828 | — | IC50 | - | — | - | |
| CHEMBL5174427 | — | IC50 | - | — | - | |
| CHEMBL5194595 | — | IC50 | - | — | - | |
| CHEMBL5204526 | — | IC50 | - | — | - | |
| CHEMBL5200527 | — | IC50 | - | — | - | |
| CHEMBL5204000 | — | IC50 | - | — | - |