Assay Detail
Functional
CHEMBL5165815
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human osimertinib-resistant PC-9 cells harboring EGFR 19 del/T790M/C797S mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-9 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.77 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5193609 | — | — | 1 | 9.19 |
| CHEMBL3545311 | BRIGATINIB | 4.0 | 1 | 8.84 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 8.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5193609 | — | IC50 | = | 0.644 | nM | 9.19 |
| CHEMBL3545311 | BRIGATINIB | IC50 | = | 1.454 | nM | 8.84 |
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 5.431 | nM | 8.27 |