Assay Detail
Binding
CHEMBL5165819
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Inhibition of wild type EGFR (unknown origin) by ELISA
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.53 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5185864 | — | — | 1 | 7.25 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 6.92 |
| CHEMBL3545311 | BRIGATINIB | 4.0 | 1 | 6.86 |
| CHEMBL5205581 | — | — | 1 | 6.63 |
| CHEMBL5172251 | — | — | 1 | 6.58 |
| CHEMBL5193609 | — | — | 1 | 6.51 |
| CHEMBL5206683 | — | — | 1 | 6.46 |
| CHEMBL5209545 | — | — | 1 | 6.38 |
| CHEMBL5185922 | — | — | 1 | 6.33 |
| CHEMBL5180778 | — | — | 1 | 6.26 |
| CHEMBL5176897 | — | — | 1 | 6.09 |
| CHEMBL5197952 | — | — | 1 | 6.05 |
| CHEMBL5172338 | — | — | 1 | - |
| CHEMBL5207083 | — | — | 1 | - |
| CHEMBL5198314 | — | — | 1 | - |
| CHEMBL5200598 | — | — | 1 | - |
| CHEMBL5188281 | — | — | 1 | - |
| CHEMBL5179495 | — | — | 1 | - |
| CHEMBL5195358 | — | — | 1 | - |
| CHEMBL5185999 | — | — | 1 | - |
| CHEMBL5188272 | — | — | 1 | - |
| CHEMBL5201250 | — | — | 1 | - |
| CHEMBL5194174 | — | — | 1 | - |
| CHEMBL5179214 | — | — | 1 | - |
| CHEMBL5181684 | — | — | 1 | - |
| CHEMBL5170653 | — | — | 1 | - |
| CHEMBL5169943 | — | — | 1 | - |
| CHEMBL5201287 | — | — | 1 | - |
| CHEMBL5181437 | — | — | 1 | - |
| CHEMBL5170303 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5185864 | — | IC50 | = | 55.9 | nM | 7.25 |
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 120.6 | nM | 6.92 |
| CHEMBL3545311 | BRIGATINIB | IC50 | = | 139.7 | nM | 6.86 |
| CHEMBL5205581 | — | IC50 | = | 236.4 | nM | 6.63 |
| CHEMBL5172251 | — | IC50 | = | 261.8 | nM | 6.58 |
| CHEMBL5193609 | — | IC50 | = | 307.5 | nM | 6.51 |
| CHEMBL5206683 | — | IC50 | = | 343.7 | nM | 6.46 |
| CHEMBL5209545 | — | IC50 | = | 413.5 | nM | 6.38 |
| CHEMBL5185922 | — | IC50 | = | 466.1 | nM | 6.33 |
| CHEMBL5180778 | — | IC50 | = | 546.6 | nM | 6.26 |
| CHEMBL5176897 | — | IC50 | = | 816.0 | nM | 6.09 |
| CHEMBL5197952 | — | IC50 | = | 885.2 | nM | 6.05 |
| CHEMBL5172338 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5207083 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5198314 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5200598 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5188281 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5179495 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5195358 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5185999 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5188272 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5201250 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5194174 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5179214 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5181684 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5170653 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5169943 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5201287 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5181437 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5170303 | — | IC50 | > | 1000.0 | nM | - |