Assay Detail
Functional
CHEMBL5166203
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human 143B cells assessed as inhibition of cell growth incubated for 48 hrs by cell titer based MTS assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 143B |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 2-Amino-3-cyanothiophene Derivatives as Potent STAT3 Inhibitors for the Treatment of Osteosarcoma Growth and Metastasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 6.15 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5174100 | — | — | 1 | 6.72 |
| CHEMBL5178793 | — | — | 1 | 6.72 |
| CHEMBL5187878 | — | — | 1 | 6.68 |
| CHEMBL5204232 | — | — | 1 | 6.64 |
| CHEMBL5198642 | — | — | 1 | 6.62 |
| CHEMBL5175754 | — | — | 1 | 6.62 |
| CHEMBL5182175 | — | — | 1 | 6.60 |
| CHEMBL5189188 | — | — | 1 | 6.60 |
| CHEMBL5200579 | — | — | 1 | 6.57 |
| CHEMBL5175326 | — | — | 1 | 6.52 |
| CHEMBL5204995 | — | — | 1 | 6.51 |
| CHEMBL5190710 | — | — | 1 | 6.44 |
| CHEMBL5191548 | — | — | 1 | 6.37 |
| CHEMBL5182473 | — | — | 1 | 6.17 |
| CHEMBL5183496 | — | — | 1 | 6.12 |
| CHEMBL5205930 | — | — | 1 | 6.02 |
| CHEMBL5201403 | — | — | 1 | 6.01 |
| CHEMBL5189287 | — | — | 1 | 5.91 |
| CHEMBL5189620 | — | — | 1 | 5.89 |
| CHEMBL5200555 | — | — | 1 | 5.89 |
| CHEMBL5172483 | — | — | 1 | 5.87 |
| CHEMBL5171914 | — | — | 1 | 5.83 |
| CHEMBL5204076 | — | — | 1 | 5.74 |
| CHEMBL5192667 | — | — | 1 | 5.70 |
| CHEMBL5193771 | — | — | 1 | 5.66 |
| CHEMBL5179157 | — | — | 1 | 5.58 |
| CHEMBL5205115 | — | — | 1 | 5.56 |
| CHEMBL5204996 | — | — | 1 | 5.43 |
| CHEMBL1829876 | — | — | 1 | 5.23 |
| CHEMBL5181085 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5174100 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5178793 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5187878 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5204232 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5198642 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5175754 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5182175 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5189188 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5200579 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5175326 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5204995 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5190710 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5191548 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5182473 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL5183496 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL5205930 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL5201403 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL5189287 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL5189620 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5200555 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL5172483 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL5171914 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL5204076 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL5192667 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL5193771 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL5179157 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5205115 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL5204996 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL1829876 | — | IC50 | = | 5870.0 | nM | 5.23 |
| CHEMBL5199357 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5196232 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5207311 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5173393 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5174319 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5205917 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5206545 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5182835 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5170693 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5208089 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5178071 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5202113 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5181085 | — | IC50 | > | 5000.0 | nM | - |