Assay Detail
Binding
CHEMBL5166207
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to His-tagged STAT3 (127 to 722 residues) (unknown origin) incubated for 30 mins by MST assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 3 (CHEMBL4026) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 2-Amino-3-cyanothiophene Derivatives as Potent STAT3 Inhibitors for the Treatment of Osteosarcoma Growth and Metastasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 6.18 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5174100 | — | — | 1 | 6.51 |
| CHEMBL5178793 | — | — | 1 | 6.44 |
| CHEMBL5182175 | — | — | 1 | 6.34 |
| CHEMBL5175326 | — | — | 1 | 6.23 |
| CHEMBL5204232 | — | — | 1 | 6.19 |
| CHEMBL1829876 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5174100 | — | Kd | = | 310.0 | nM | 6.51 |
| CHEMBL5178793 | — | Kd | = | 360.0 | nM | 6.44 |
| CHEMBL5182175 | — | Kd | = | 460.0 | nM | 6.34 |
| CHEMBL5175326 | — | Kd | = | 590.0 | nM | 6.23 |
| CHEMBL5204232 | — | Kd | = | 640.0 | nM | 6.19 |
| CHEMBL1829876 | — | Kd | = | 4570.0 | nM | 5.34 |