Assay Detail
Binding
CHEMBL5166511
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]NCS-382 binding to CaMK2alpha in rat cerebrocortical membranes
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CHEMBL2359) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery and Optimization of 5-Hydroxy-Diclofenac toward a New Class of Ligands with Nanomolar Affinity for the CaMKIIα Hub Domain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 9.29 | 9.89 |
| Ki | 2 | 6.30 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190035 | 3-Hydroxyphenylacetate | — | 2 | 9.89 |
| CHEMBL240714 | — | — | 2 | 8.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190035 | 3-Hydroxyphenylacetate | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL240714 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL190035 | 3-Hydroxyphenylacetate | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL240714 | — | Ki | = | 1995.26 | nM | 5.70 |