Assay Detail
Binding
CHEMBL5166512
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Inhibition of [3H]NCS-382 binding to CaMK2alpha (unknown origin)
8
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CHEMBL4147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and Optimization of 5-Hydroxy-Diclofenac toward a New Class of Ligands with Nanomolar Affinity for the CaMKIIα Hub Domain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.93 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5175277 | — | — | 1 | 7.46 |
| CHEMBL1772 | — | — | 2 | 5.70 |
| CHEMBL1030 | 4'-HYDROXY-DICLOFENAC | — | 2 | 5.70 |
| CHEMBL1342 | OXYBATE | 4.0 | 1 | 5.37 |
| CHEMBL27246 | CINNAMIC ACID | — | 1 | - |
| CHEMBL66879 | COUMARIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5175277 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL1772 | — | Ki | = | 1995.26 | nM | 5.70 |
| CHEMBL1030 | 4'-HYDROXY-DICLOFENAC | Ki | = | 1995.26 | nM | 5.70 |
| CHEMBL1030 | 4'-HYDROXY-DICLOFENAC | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL1772 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL1342 | OXYBATE | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL27246 | CINNAMIC ACID | Ki | > | 100000.0 | nM | - |
| CHEMBL66879 | COUMARIC ACID | Ki | > | 100000.0 | nM | - |