Compound Detail
CHEMBL1342
OXYBATE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1342 |
| Name | OXYBATE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | SJZRECIVHVDYJC-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
5
Targets
17
Activities
3
Assay Types
0
PK Parameters
20
Publications
4
Known Names
Molecular Properties
104.1
MW (Da)
-0.16
ALogP
2
HBA
2
HBD
57.5
PSA (Ų)
0.52
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2002 |
| Availability | Prescription |
| Chirality | Achiral |
Activity Summary
Ki 12 meas. best 5.52
IC50 4 meas. best 5.94
EC50 1 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 5.94 | 5.94 | 1140.0 | 2 |
| Calcium/calmodulin-dependent protein kinase type II subunit alpha CHEMBL2359 | Ki | 5.52 | 5.06 | 3000.0 | 3 |
| Unchecked CHEMBL612545 | Ki | 5.44 | 5.3983 | 3600.0 | 6 |
| GABA-A receptor; anion channel CHEMBL1907607 | Ki | 5.37 | 5.37 | 4300.0 | 1 |
| Calcium/calmodulin-dependent protein kinase type II subunit alpha CHEMBL4147 | Ki | 5.37 | 5.37 | 4300.0 | 1 |
| Gamma-hydroxybutyrate receptor CHEMBL3558 | IC50 | 5.18 | 4.89 | 6600.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine