Assay Detail
Binding
CHEMBL678439
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Binding affinity towards [3H]GHB binding site
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Analogues of gamma-hydroxybutyric acid. Synthesis and binding studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.52 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL171331 | — | — | 1 | 8.48 |
| CHEMBL354804 | — | — | 1 | 8.46 |
| CHEMBL171595 | — | — | 1 | 7.96 |
| CHEMBL1342 | OXYBATE | 4.0 | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL171331 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL354804 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL171595 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1342 | OXYBATE | IC50 | = | 6600.0 | nM | 5.18 |