Gamma-hydroxybutyrate receptor · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt Q6RY99. Use UniProt Q6RY99 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q6RY99 as the stable identity anchor, then attach disease evidence before program review.
Gamma-hydroxybutyrate receptor
Review this target as Gamma-hydroxybutyrate receptor, mapped to UniProt Q6RY99. Sequence length is 512 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Gamma-hydroxybutyrate receptor as ChEMBL target CHEMBL3558, mapped to UniProt Q6RY99. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Gamma-hydroxybutyrate receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | Q6RY99 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Gamma-hydroxybutyrate receptor |
| UniProt Accession | Q6RY99 |
| Component Type | Protein |
| Sequence Length | 512 aa |
Gamma-hydroxybutyrate receptor
Review this target as Gamma-hydroxybutyrate receptor, mapped to UniProt Q6RY99. Sequence length is 512 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL171331 | 8.48 | IC50 | 3.3 | Preclinical |
| CHEMBL354804 | 8.46 | IC50 | 3.5 | Preclinical |
| CHEMBL171595 | 7.96 | IC50 | 11.0 | Preclinical |
| CHEMBL514926 | 6.4 | IC50 | 400.0 | Preclinical |
| CHEMBL472694 | 6.3 | IC50 | 500.0 | Preclinical |
| CHEMBL189853 | 5.35 | IC50 | 4500.0 | Preclinical |
| CHEMBL1342 | 5.18 | IC50 | 6600.0 | Approved |
| CHEMBL190961 | 5.08 | IC50 | 8300.0 | Preclinical |
| CHEMBL190035 | 4.92 | IC50 | 12000.0 | Preclinical |
| CHEMBL107066 | 4.79 | IC50 | 16300.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell membrane format | 5 | 10 | 5.2 |
| single protein format | 4 | 4 | 7.5 |