Assay Detail
Binding
CHEMBL5166838
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Inhibition of biotinylated Eu-W1024 streptavidin-labeled MAGEA4 (unknown origin) expressed in Escherichia coli BL21-(DE3)/GST-tagged RAD18 (unknown origin) (267 to 402 residues) interaction using Ulight-anti-GST antibody incubated for 30 to 60 mins by LANCE TR-FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and Structural Basis of the Selectivity of Potent Cyclic Peptide Inhibitors of MAGE-A4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.78 | 7.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5199001 | — | — | 1 | 7.87 |
| CHEMBL5188210 | — | — | 1 | 7.68 |
| CHEMBL5187815 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5199001 | — | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL5188210 | — | IC50 | = | 20.9 | nM | 7.68 |
| CHEMBL5187815 | — | IC50 | < | 10.0 | nM | - |