Compound Detail
CHEMBL5187815
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CC(C)C[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CS)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O
Basic Information
| ChEMBL ID | CHEMBL5187815 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DFCAXDPZUGKTHK-XMKKDGKYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
1905.2
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 2 meas. best 8.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanoma-associated antigen 4 CHEMBL4296022 | Kd | 8.19 | 8.06 | 6.5 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanoma-associated antigen 4 | Kd | = | 6.5 | nM | 8.19 | Binding affinity to recombinant N-terminal His-tagged MAGEA4-MH domain (unknown ... | 35522528 |
| Melanoma-associated antigen 4 | Kd | = | 11.8 | nM | 7.93 | Binding affinity to MAGEA4 (unknown origin) expressed in Escherichia coli BL21-(... | 35522528 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35522528 | 10.1021/acs.jmedchem.2c00185 | Melanoma-associated antigen 4 | 3 |
| 35522528 | 10.1021/acs.jmedchem.2c00185 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine