Assay Detail
Binding
CHEMBL5166985
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant full length His tagged human CDK8/Cyclin C expressed in Baculovirus incubated for 60 mins in presence of ATP by ADP-Glo kinase assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery and Anti-Inflammatory Activity Evaluation of a Novel CDK8 Inhibitor through Upregulation of IL-10 for the Treatment of Inflammatory Bowel Disease <i>In Vivo</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.63 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5199685 | — | — | 1 | 7.25 |
| CHEMBL5197084 | — | — | 1 | 7.19 |
| CHEMBL5185339 | — | — | 1 | 7.16 |
| CHEMBL5176173 | — | — | 1 | 7.14 |
| CHEMBL5194157 | — | — | 1 | 7.12 |
| CHEMBL5182399 | — | — | 1 | 7.10 |
| CHEMBL5178431 | — | — | 1 | 7.10 |
| CHEMBL5190284 | — | — | 1 | 7.09 |
| CHEMBL5174097 | — | — | 1 | 7.06 |
| CHEMBL5177563 | — | — | 1 | 7.02 |
| CHEMBL5209397 | — | — | 1 | 6.98 |
| CHEMBL5206315 | — | — | 1 | 6.95 |
| CHEMBL5195098 | — | — | 1 | 6.87 |
| CHEMBL5194000 | — | — | 1 | 6.87 |
| CHEMBL5208801 | — | — | 1 | 6.84 |
| CHEMBL5169782 | — | — | 1 | 6.81 |
| CHEMBL5175354 | — | — | 1 | 6.79 |
| CHEMBL5188393 | — | — | 1 | 6.75 |
| CHEMBL5180489 | — | — | 1 | 6.72 |
| CHEMBL5188999 | — | — | 1 | 6.69 |
| CHEMBL1409113 | — | — | 1 | 6.68 |
| CHEMBL5196466 | — | — | 1 | 6.68 |
| CHEMBL5174635 | — | — | 1 | 6.67 |
| CHEMBL5196442 | — | — | 1 | 6.63 |
| CHEMBL5181302 | — | — | 1 | 6.58 |
| CHEMBL5198747 | — | — | 1 | 6.28 |
| CHEMBL5181742 | — | — | 1 | 6.26 |
| CHEMBL5175136 | — | — | 1 | 6.02 |
| CHEMBL5193697 | — | — | 1 | 5.98 |
| CHEMBL5177445 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5199685 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL5197084 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL5185339 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5176173 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL5194157 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL5182399 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5178431 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5190284 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL5174097 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL5177563 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL5209397 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL5206315 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL5195098 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL5194000 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL5208801 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL5169782 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL5175354 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL5188393 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL5180489 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5188999 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL1409113 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL5196466 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5174635 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL5196442 | — | IC50 | = | 234.0 | nM | 6.63 |
| CHEMBL5181302 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5198747 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5181742 | — | IC50 | = | 548.0 | nM | 6.26 |
| CHEMBL5175136 | — | IC50 | = | 947.0 | nM | 6.02 |
| CHEMBL5193697 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL5177445 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL5188825 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL5194811 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL5179301 | — | IC50 | = | 3654.0 | nM | 5.44 |
| CHEMBL16171 | WOGONIN | IC50 | = | 5900.0 | nM | 5.23 |