Assay Detail
Binding
CHEMBL5167057
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full length His-tagged p38gamma expressed in baculovirus expression system preincubated for 2 hrs followed by ATP addition and measured after 1 hr by Alpha screen assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Characterization of Inhaled p38α/β MAPK Inhibitors for the Treatment of Lung Inflammatory Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.71 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5197888 | — | — | 1 | 8.00 |
| CHEMBL5184542 | — | — | 1 | 7.80 |
| CHEMBL5206328 | — | — | 1 | 6.79 |
| CHEMBL5174953 | — | — | 1 | 6.09 |
| CHEMBL5202475 | — | — | 1 | 6.03 |
| CHEMBL5208103 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5197888 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5184542 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5206328 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL5174953 | — | IC50 | = | 805.0 | nM | 6.09 |
| CHEMBL5202475 | — | IC50 | = | 944.0 | nM | 6.03 |
| CHEMBL5208103 | — | IC50 | = | 2856.0 | nM | 5.54 |