Assay Detail
Binding
CHEMBL5167633
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate measured after 1 hr in presence of ATP by ADP-glo luminescence assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and Optimization of Thienopyrimidine Derivatives as Potent and Selective PI3Kδ Inhibitors for the Treatment of B-Cell Malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.43 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3643413 | LENIOLISIB | 4.0 | 1 | 8.82 |
| CHEMBL5192588 | — | — | 1 | 8.66 |
| CHEMBL5203775 | — | — | 1 | 8.48 |
| CHEMBL5178373 | — | — | 1 | 8.33 |
| CHEMBL5204818 | — | — | 1 | 8.24 |
| CHEMBL5178942 | — | — | 1 | 8.07 |
| CHEMBL5174889 | — | — | 1 | 8.00 |
| CHEMBL5188347 | — | — | 1 | 8.00 |
| CHEMBL5177854 | — | — | 1 | 7.96 |
| CHEMBL5175244 | — | — | 1 | 7.92 |
| CHEMBL5179250 | — | — | 1 | 7.68 |
| CHEMBL5205011 | — | — | 1 | 7.58 |
| CHEMBL5196839 | — | — | 1 | 7.52 |
| CHEMBL5199087 | — | — | 1 | 7.43 |
| CHEMBL5179550 | — | — | 1 | 7.42 |
| CHEMBL5190613 | — | — | 1 | 7.35 |
| CHEMBL5185603 | — | — | 1 | 7.28 |
| CHEMBL5182641 | — | — | 1 | 7.27 |
| CHEMBL5171306 | — | — | 1 | 7.26 |
| CHEMBL5194806 | — | — | 1 | 7.22 |
| CHEMBL5205397 | — | — | 1 | 7.01 |
| CHEMBL5208623 | — | — | 1 | 6.99 |
| CHEMBL5202530 | — | — | 1 | 6.89 |
| CHEMBL5188346 | — | — | 1 | 6.87 |
| CHEMBL5208539 | — | — | 1 | 6.81 |
| CHEMBL5184666 | — | — | 1 | 6.74 |
| CHEMBL5181233 | — | — | 1 | 6.57 |
| CHEMBL5202548 | — | — | 1 | 6.34 |
| CHEMBL5206003 | — | — | 1 | 6.33 |
| CHEMBL5187872 | — | — | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3643413 | LENIOLISIB | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5192588 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL5203775 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL5178373 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL5204818 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL5178942 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL5174889 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5188347 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5177854 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5175244 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5179250 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5205011 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5196839 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5199087 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5179550 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL5190613 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5185603 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5182641 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL5171306 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5194806 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5205397 | — | IC50 | = | 97.5 | nM | 7.01 |
| CHEMBL5208623 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL5202530 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL5188346 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL5208539 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL5184666 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL5181233 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL5202548 | — | IC50 | = | 458.0 | nM | 6.34 |
| CHEMBL5206003 | — | IC50 | = | 465.0 | nM | 6.33 |
| CHEMBL5187872 | — | IC50 | = | 1014.0 | nM | 5.99 |