Compound Detail
CHEMBL5187872
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Basic Information
| ChEMBL ID | CHEMBL5187872 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NWJRWDCKCSRHFK-AWEZNQCLSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
395.5
MW (Da)
3.79
ALogP
6
HBA
1
HBD
81.9
PSA (Ų)
0.73
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.99
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform CHEMBL3130 | IC50 | 5.99 | 5.99 | 1014.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | IC50 | = | 1014.0 | nM | 5.99 | Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate measured after ... | 35609190 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35609190 | 10.1021/acs.jmedchem.2c00530 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1 |
| 35609190 | 10.1021/acs.jmedchem.2c00530 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 1 |
| 35609190 | 10.1021/acs.jmedchem.2c00530 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine