Assay Detail
Binding
CHEMBL5167640
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kbeta in LPA stimulated human PC-3 cells incubated for 10 mins by AlphaLISA assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and Optimization of Thienopyrimidine Derivatives as Potent and Selective PI3Kδ Inhibitors for the Treatment of B-Cell Malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.36 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3643413 | LENIOLISIB | 4.0 | 1 | 5.57 |
| CHEMBL5192588 | — | — | 1 | 5.38 |
| CHEMBL5204818 | — | — | 1 | 5.29 |
| CHEMBL5203775 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3643413 | LENIOLISIB | IC50 | = | 2683.7 | nM | 5.57 |
| CHEMBL5192588 | — | IC50 | = | 4211.2 | nM | 5.38 |
| CHEMBL5204818 | — | IC50 | = | 5116.2 | nM | 5.29 |
| CHEMBL5203775 | — | IC50 | = | 6201.3 | nM | 5.21 |