Assay Detail
Binding
CHEMBL5167641
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kgamma in C5a stimulated mouse RAW264.7 cells incubated for 10 mins by AlphaLisa assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL2189158) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Design and Optimization of Thienopyrimidine Derivatives as Potent and Selective PI3Kδ Inhibitors for the Treatment of B-Cell Malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.26 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3643413 | LENIOLISIB | 4.0 | 1 | 5.39 |
| CHEMBL5192588 | — | — | 1 | 5.32 |
| CHEMBL5203775 | — | — | 1 | 5.22 |
| CHEMBL5204818 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3643413 | LENIOLISIB | IC50 | = | 4037.4 | nM | 5.39 |
| CHEMBL5192588 | — | IC50 | = | 4780.4 | nM | 5.32 |
| CHEMBL5203775 | — | IC50 | = | 5991.2 | nM | 5.22 |
| CHEMBL5204818 | — | IC50 | = | 8060.2 | nM | 5.09 |