Assay Detail
ADMET
CHEMBL5167767
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate incubated for 5 to 45 mins in presence of NADPH by LC/MS analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Novel Series of Imipridone Compounds as <i>Homo sapiens</i> Caseinolytic Protease P Agonists with Potent Antitumor Activities In Vitro and In Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.68 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1503 | OMEPRAZOLE | 4.0 | 1 | 5.68 |
| CHEMBL5191392 | — | — | 1 | - |
| CHEMBL4297310 | DORDAVIPRONE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1503 | OMEPRAZOLE | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL5191392 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4297310 | DORDAVIPRONE | IC50 | > | 10000.0 | nM | - |