Assay Detail
Functional
CHEMBL5168043
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anticancer activity against human MOLM-13 cells harbouring MLL-AF9 assessed as inhibition of cell growth treated for 6 days measured by CCK-8 kit method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLM-13 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluations of DOT1L Peptide Mimetics Targeting the Protein-Protein Interactions between DOT1L and MLL-AF9/MLL-ENL.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.60 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3414626 | PINOMETOSTAT | 2.0 | 1 | 7.14 |
| CHEMBL5198951 | — | — | 1 | 6.42 |
| CHEMBL5187149 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3414626 | PINOMETOSTAT | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL5198951 | — | IC50 | = | 382.0 | nM | 6.42 |
| CHEMBL5187149 | — | IC50 | = | 589.0 | nM | 6.23 |