Assay Detail
Binding
CHEMBL5168103
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Inhibition of wild type FGFR1 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISA
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 1,6-Naphthyridin-2(1<i>H</i>)-one Derivatives as Novel, Potent, and Selective FGFR4 Inhibitors for the Treatment of Hepatocellular Carcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.39 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5175788 | — | — | 1 | 8.38 |
| CHEMBL5180280 | — | — | 1 | 8.08 |
| CHEMBL5185308 | — | — | 1 | 7.77 |
| CHEMBL5181533 | — | — | 1 | 7.52 |
| CHEMBL5186034 | — | — | 1 | 7.34 |
| CHEMBL5202677 | — | — | 1 | 7.31 |
| CHEMBL5189122 | — | — | 1 | 7.28 |
| CHEMBL5200589 | — | — | 1 | 7.09 |
| CHEMBL5193663 | — | — | 1 | 7.01 |
| CHEMBL5192973 | — | — | 1 | 6.72 |
| CHEMBL5204828 | — | — | 1 | 6.66 |
| CHEMBL5173719 | — | — | 1 | 6.62 |
| CHEMBL5173193 | — | — | 1 | 6.55 |
| CHEMBL5186125 | — | — | 1 | 6.28 |
| CHEMBL5172762 | — | — | 1 | 6.20 |
| CHEMBL5188086 | — | — | 1 | 6.10 |
| CHEMBL5191143 | — | — | 1 | 6.10 |
| CHEMBL4514636 | FISOGATINIB | 2.0 | 1 | 6.02 |
| CHEMBL5176617 | — | — | 1 | 6.01 |
| CHEMBL5203036 | — | — | 1 | 5.85 |
| CHEMBL5190597 | — | — | 1 | 5.71 |
| CHEMBL5192694 | — | — | 1 | 5.60 |
| CHEMBL5170061 | — | — | 1 | 5.55 |
| CHEMBL5184648 | — | — | 1 | 5.52 |
| CHEMBL5200584 | — | — | 1 | 5.51 |
| CHEMBL5189713 | — | — | 1 | 5.43 |
| CHEMBL5194694 | — | — | 1 | 5.39 |
| CHEMBL5186071 | — | — | 1 | 5.39 |
| CHEMBL5179371 | — | — | 1 | 5.38 |
| CHEMBL5206076 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5175788 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL5180280 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL5185308 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5181533 | — | IC50 | = | 30.4 | nM | 7.52 |
| CHEMBL5186034 | — | IC50 | = | 45.7 | nM | 7.34 |
| CHEMBL5202677 | — | IC50 | = | 48.5 | nM | 7.31 |
| CHEMBL5189122 | — | IC50 | = | 52.8 | nM | 7.28 |
| CHEMBL5200589 | — | IC50 | = | 80.8 | nM | 7.09 |
| CHEMBL5193663 | — | IC50 | = | 96.6 | nM | 7.01 |
| CHEMBL5192973 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL5204828 | — | IC50 | = | 221.0 | nM | 6.66 |
| CHEMBL5173719 | — | IC50 | = | 240.8 | nM | 6.62 |
| CHEMBL5173193 | — | IC50 | = | 281.0 | nM | 6.55 |
| CHEMBL5186125 | — | IC50 | = | 527.0 | nM | 6.28 |
| CHEMBL5172762 | — | IC50 | = | 637.0 | nM | 6.20 |
| CHEMBL5188086 | — | IC50 | = | 799.0 | nM | 6.10 |
| CHEMBL5191143 | — | IC50 | = | 791.0 | nM | 6.10 |
| CHEMBL4514636 | FISOGATINIB | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL5176617 | — | IC50 | = | 983.0 | nM | 6.01 |
| CHEMBL5203036 | — | IC50 | = | 1422.0 | nM | 5.85 |
| CHEMBL5190597 | — | IC50 | = | 1952.0 | nM | 5.71 |
| CHEMBL5192694 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL5170061 | — | IC50 | = | 2799.0 | nM | 5.55 |
| CHEMBL5184648 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5200584 | — | IC50 | = | 3069.0 | nM | 5.51 |
| CHEMBL5189713 | — | IC50 | = | 3731.0 | nM | 5.43 |
| CHEMBL5186071 | — | IC50 | = | 4041.0 | nM | 5.39 |
| CHEMBL5194694 | — | IC50 | = | 4028.0 | nM | 5.39 |
| CHEMBL5179371 | — | IC50 | = | 4129.0 | nM | 5.38 |
| CHEMBL5206076 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL5202150 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5196437 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5176243 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5193780 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5188499 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5204303 | — | IC50 | > | 5000.0 | nM | - |