Assay Detail
ADMET
CHEMBL5168155
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP2B6 in human liver microsomes
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 1,6-Naphthyridin-2(1<i>H</i>)-one Derivatives as Novel, Potent, and Selective FGFR4 Inhibitors for the Treatment of Hepatocellular Carcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.69 | 4.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5200584 | — | — | 1 | 4.72 |
| CHEMBL4514636 | FISOGATINIB | 2.0 | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5200584 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL4514636 | FISOGATINIB | IC50 | = | 21780.0 | nM | 4.66 |