Assay Detail
Binding
CHEMBL5168664
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human alpha1c/beta2a/alpha2delta1 Cav1.2 expressed in HEK293 cells assessed as Ca2+ current at -80 mV holding potential by patch clamp technique
2
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
L-type calcium channel alpha-1c/beta-2/alpha2delta-1 (CHEMBL4106164) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Structural Modifications of Nimodipine Lead to Novel PDE1 Inhibitors with Anti-pulmonary Fibrosis Effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.53 | 7.53 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1428 | NIMODIPINE | 4.0 | 1 | 7.53 |
| CHEMBL5180169 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1428 | NIMODIPINE | IC50 | = | 29.8 | nM | 7.53 |
| CHEMBL5180169 | — | Inhibition | - | % | - |