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CHEMBL4106164 Target Snapshot

L-type calcium channel alpha-1c/beta-2/alpha2delta-1 · PROTEIN COMPLEX · Homo sapiens

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6Compounds
8Assays
1Approved Drugs
5.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P54289. Use UniProt P54289 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P54289 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Protein anchor
Voltage-dependent calcium channel subunit alpha-2/delta-1

Voltage-dependent calcium channel subunit alpha-2/delta-1

Review this target as L-type calcium channel alpha-1c/beta-2/alpha2delta-1, mapped to UniProt P54289. ChEMBL maps the protein component as Voltage-dependent calcium channel subunit alpha-2/delta-1. Sequence length is 1103 aa.

Protein source · UniProt accession via ChEMBL component mapping
UniProt P54289 Protein 1103 aa
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Identity Layer

Cross-source identity

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This review treats L-type calcium channel alpha-1c/beta-2/alpha2delta-1 as ChEMBL target CHEMBL4106164, mapped to UniProt P54289. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
L-type calcium channel alpha-1c/beta-2/alpha2delta-1
PROTEIN COMPLEX · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4106164
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P54289
Voltage-dependent calcium channel subunit alpha-2/delta-1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

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UniProt Target Context
UniProt accession via ChEMBL component mapping

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
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Overview

Basic Information

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Preferred NameL-type calcium channel alpha-1c/beta-2/alpha2delta-1
Target TypePROTEIN COMPLEX
OrganismHomo sapiens
UniProtP54289
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelVoltage-dependent calcium channel subunit alpha-2/delta-1
UniProt AccessionP54289
Component TypeProtein
Sequence Length1103 aa

Voltage-dependent calcium channel subunit alpha-2/delta-1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as L-type calcium channel alpha-1c/beta-2/alpha2delta-1, mapped to UniProt P54289. ChEMBL maps the protein component as Voltage-dependent calcium channel subunit alpha-2/delta-1. Sequence length is 1103 aa.

Mapped IDP54289
Review nameL-type calcium channel alpha-1c/beta-2/alpha2delta-1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC505.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1428 7.53 IC50 29.8 Approved
CHEMBL71260 4.38 IC50 41300.0 Preclinical
CHEMBL4874732 4.17 IC50 67300.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

NIMODIPINE
CHEMBL1428
Approved 1988
Properties Compare Identifier
Assay Landscape

Assay Landscape

8
Total Assays
3
Tested Compounds
3
Assay Types
Binding — 6 assays, 3 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 6 3 5.4
ADME — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0 —
Toxicity — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine