Compound Detail
CHEMBL4874732
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4874732 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HNKFWEHJGWDEPK-FQEVSTJZSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
312.5
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| L-type calcium channel alpha-1c/beta-2/alpha2delta-1 CHEMBL4106164 | IC50 | 4.17 | 4.17 | 67300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| L-type calcium channel alpha-1c/beta-2/alpha2delta-1 | IC50 | = | 67300.0 | nM | 4.17 | Inhibition of human alpha1c/beta2a/alpha2delta1 Cav1.2 expressed in HEK293 cells... | 34319736 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34319736 | 10.1021/acs.jnatprod.1c00136 | PC-12 | 13 |
| 34319736 | 10.1021/acs.jnatprod.1c00136 | L-type calcium channel alpha-1c/beta-2/alpha2delta-1 | 5 |
Data from ChEMBL 36 via Core Engine