Assay Detail
Binding
CHEMBL5168686
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant AKT2 (120 to 481 end residues) (unknown origin) catalytic domain expressed in Sf21 cells using peptide substrate incubated for 1 hr in presence of ATP by caliper off-chip mobility shift assay
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-beta serine/threonine-protein kinase (CHEMBL2431) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Clinical Candidate NTQ1062 as a Potent and Bioavailable Akt Inhibitor for the Treatment of Human Tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 7.38 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5197007 | — | — | 1 | 8.92 |
| CHEMBL5189707 | — | — | 1 | 8.31 |
| CHEMBL5182446 | — | — | 1 | 8.24 |
| CHEMBL5187287 | — | — | 1 | 8.22 |
| CHEMBL5169427 | — | — | 1 | 8.20 |
| CHEMBL5193325 | — | — | 1 | 8.16 |
| CHEMBL5192188 | — | — | 1 | 7.96 |
| CHEMBL5175332 | — | — | 1 | 7.96 |
| CHEMBL5189610 | — | — | 1 | 7.82 |
| CHEMBL5190647 | — | — | 1 | 7.82 |
| CHEMBL5185923 | — | — | 1 | 7.68 |
| CHEMBL5195664 | — | — | 1 | 7.64 |
| CHEMBL5206905 | — | — | 1 | 7.62 |
| CHEMBL5199199 | — | — | 1 | 7.55 |
| CHEMBL5187546 | — | — | 1 | 7.54 |
| CHEMBL5180219 | — | — | 1 | 7.48 |
| CHEMBL5175628 | — | — | 1 | 7.40 |
| CHEMBL5174965 | — | — | 1 | 7.40 |
| CHEMBL5190230 | — | — | 1 | 7.34 |
| CHEMBL2177390 | IPATASERTIB | 3.0 | 1 | 7.32 |
| CHEMBL5195745 | — | — | 1 | 7.20 |
| CHEMBL5177491 | — | — | 1 | 7.15 |
| CHEMBL5187508 | — | — | 1 | 7.14 |
| CHEMBL5169446 | — | — | 1 | 7.02 |
| CHEMBL5172419 | — | — | 1 | 6.78 |
| CHEMBL5171561 | — | — | 1 | 6.77 |
| CHEMBL5187172 | — | — | 1 | 6.66 |
| CHEMBL5188472 | — | — | 1 | 6.53 |
| CHEMBL5194492 | — | — | 1 | 6.50 |
| CHEMBL5181964 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5197007 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5189707 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL5182446 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL5187287 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5169427 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL5193325 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL5192188 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5175332 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5189610 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5190647 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5185923 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5195664 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5206905 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5199199 | — | IC50 | = | 28.2 | nM | 7.55 |
| CHEMBL5187546 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5180219 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5175628 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5174965 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5190230 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL2177390 | IPATASERTIB | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL5195745 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL5177491 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL5187508 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL5169446 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL5172419 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL5171561 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL5187172 | — | IC50 | = | 221.0 | nM | 6.66 |
| CHEMBL5188472 | — | IC50 | = | 293.0 | nM | 6.53 |
| CHEMBL5194492 | — | IC50 | = | 314.0 | nM | 6.50 |
| CHEMBL5181964 | — | IC50 | = | 394.0 | nM | 6.41 |
| CHEMBL5183601 | — | IC50 | = | 475.0 | nM | 6.32 |
| CHEMBL5198109 | — | IC50 | = | 504.0 | nM | 6.30 |
| CHEMBL5188354 | — | IC50 | = | 542.0 | nM | 6.27 |
| CHEMBL5177946 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5175305 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5181308 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5206091 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5176995 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5193935 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5200967 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5189748 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5205187 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5172329 | — | IC50 | > | 1000.0 | nM | - |