Assay Detail
Binding
CHEMBL5168687
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant N-terminal GST tagged AKT2 (108 to 479 end residues) (unknown origin) catalytic domain expressed in Sf21 cells using peptide substrate incubated for 1 hr in presence of ATP by caliper off-chip mobility shift assay
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-gamma serine/threonine-protein kinase (CHEMBL4816) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Clinical Candidate NTQ1062 as a Potent and Bioavailable Akt Inhibitor for the Treatment of Human Tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 8.48 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5182446 | — | — | 1 | 10.00 |
| CHEMBL5197007 | — | — | 1 | 10.00 |
| CHEMBL5169427 | — | — | 1 | 10.00 |
| CHEMBL5195745 | — | — | 1 | 9.70 |
| CHEMBL5175628 | — | — | 1 | 9.70 |
| CHEMBL5175332 | — | — | 1 | 9.70 |
| CHEMBL5190230 | — | — | 1 | 9.70 |
| CHEMBL5180219 | — | — | 1 | 9.70 |
| CHEMBL5177491 | — | — | 1 | 9.52 |
| CHEMBL5206905 | — | — | 1 | 9.52 |
| CHEMBL5195664 | — | — | 1 | 9.40 |
| CHEMBL5189707 | — | — | 1 | 9.40 |
| CHEMBL5193325 | — | — | 1 | 9.30 |
| CHEMBL5187172 | — | — | 1 | 9.30 |
| CHEMBL5171561 | — | — | 1 | 9.30 |
| CHEMBL5187508 | — | — | 1 | 9.15 |
| CHEMBL5189610 | — | — | 1 | 9.00 |
| CHEMBL5192188 | — | — | 1 | 8.92 |
| CHEMBL5199199 | — | — | 1 | 8.92 |
| CHEMBL5187287 | — | — | 1 | 8.80 |
| CHEMBL5190647 | — | — | 1 | 8.59 |
| CHEMBL5174965 | — | — | 1 | 8.36 |
| CHEMBL5172419 | — | — | 1 | 8.18 |
| CHEMBL5185923 | — | — | 1 | 8.13 |
| CHEMBL5187546 | — | — | 1 | 8.13 |
| CHEMBL5188472 | — | — | 1 | 8.12 |
| CHEMBL5175305 | — | — | 1 | 8.07 |
| CHEMBL5194492 | — | — | 1 | 8.04 |
| CHEMBL5169446 | — | — | 1 | 7.92 |
| CHEMBL5188354 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5182446 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL5169427 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL5197007 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL5195745 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5175628 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5175332 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5190230 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5180219 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5177491 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL5206905 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL5195664 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5189707 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5193325 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5171561 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5187172 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5187508 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5189610 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5192188 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5199199 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5187287 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5190647 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL5174965 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL5172419 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL5185923 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL5187546 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL5188472 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL5175305 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL5194492 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL5169446 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5188354 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5198109 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2177390 | IPATASERTIB | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5181964 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5193935 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5181308 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5183601 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5200967 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL5189748 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5205187 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL5176995 | — | IC50 | = | 661.0 | nM | 6.18 |
| CHEMBL5177946 | — | IC50 | = | 953.0 | nM | 6.02 |
| CHEMBL5206091 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5172329 | — | IC50 | > | 1000.0 | nM | - |