Assay Detail
Functional
CHEMBL5168688
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Antiproliferative activity against human LNcap assessed as reduction in cell viability incubated for 72 hrs by Cell Titer Glo luminescent assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Clinical Candidate NTQ1062 as a Potent and Bioavailable Akt Inhibitor for the Treatment of Human Tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.84 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5169427 | — | — | 1 | 7.30 |
| CHEMBL5195745 | — | — | 1 | 7.10 |
| CHEMBL5189707 | — | — | 1 | 7.08 |
| CHEMBL5206905 | — | — | 1 | 6.99 |
| CHEMBL5175628 | — | — | 1 | 6.88 |
| CHEMBL5197007 | — | — | 1 | 6.70 |
| CHEMBL5180219 | — | — | 1 | 6.63 |
| CHEMBL5190230 | — | — | 1 | 6.55 |
| CHEMBL5177491 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5169427 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5195745 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL5189707 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL5206905 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL5175628 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL5197007 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL5180219 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL5190230 | — | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL5177491 | — | IC50 | = | 446.0 | nM | 6.35 |