Assay Detail
ADMET
CHEMBL5168692
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP1A2 in human liver microsomes at 0.01 to 30 uM using phenacetin as substrate in presence of NADPH by UPLC-MS/MS analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Clinical Candidate NTQ1062 as a Potent and Bioavailable Akt Inhibitor for the Treatment of Human Tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.77 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5187508 | — | — | 1 | 5.19 |
| CHEMBL5206905 | — | — | 1 | 4.60 |
| CHEMBL5193325 | — | — | 1 | 4.52 |
| CHEMBL5169427 | — | — | 1 | - |
| CHEMBL5182446 | — | — | 1 | - |
| CHEMBL5199199 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5187508 | — | IC50 | = | 6480.0 | nM | 5.19 |
| CHEMBL5206905 | — | IC50 | = | 25200.0 | nM | 4.60 |
| CHEMBL5193325 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL5169427 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5182446 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5199199 | — | IC50 | > | 30000.0 | nM | - |