Assay Detail
Binding
CHEMBL5215147
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PROTAC activity at CRBN/BCL-XL in human MOLT-4 cells assessed as induction of BCL-XL degradation incubated for 16 hrs by Western blot analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Protein cereblon/Bcl-2-like protein 1 (CHEMBL4523705) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
PROTACs to address the challenges facing small molecule inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 7.30 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4777606 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4777606 | — | EC50 | = | 50.0 | nM | 7.30 |