Assay Detail
Binding
CHEMBL5215200
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human GST-tagged EGFR L858R/T790M mutant expressed in Sf9 insect cells using ATP as substrate by HTRF assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The new opportunities in medicinal chemistry of fourth-generation EGFR inhibitors to overcome C797S mutation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.07 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4214567 | — | — | 1 | 8.52 |
| CHEMBL4284413 | — | — | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4214567 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4284413 | — | IC50 | = | 24.0 | nM | 7.62 |