Assay Detail
Binding
CHEMBL5215211
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type EGFR (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The new opportunities in medicinal chemistry of fourth-generation EGFR inhibitors to overcome C797S mutation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.47 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL321494 | — | — | 1 | 7.62 |
| CHEMBL5218780 | — | — | 1 | 7.31 |
| CHEMBL5220061 | — | — | 1 | - |
| CHEMBL5218879 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL321494 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5218780 | — | IC50 | = | 49.2 | nM | 7.31 |
| CHEMBL5220061 | — | IC50 | < | 0.3 | nM | - |
| CHEMBL5218879 | — | IC50 | < | 0.3 | nM | - |