Assay Detail
Binding
CHEMBL5215213
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human wild type EGFR assessed as enzyme remaining activity using poly-Glu-Tyr peptide substrate incubated for 2 hrs in presence of [gamma-33P]ATP by radiometric kinase assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The new opportunities in medicinal chemistry of fourth-generation EGFR inhibitors to overcome C797S mutation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.61 | 4.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1328065 | — | — | 1 | 4.61 |
| CHEMBL4207984 | — | — | 1 | - |
| CHEMBL4214588 | — | — | 1 | - |
| CHEMBL4218431 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1328065 | — | IC50 | = | 24300.0 | nM | 4.61 |
| CHEMBL4207984 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4214588 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4218431 | — | IC50 | > | 50000.0 | nM | - |