Assay Detail
Binding
CHEMBL5215220
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human EGFR del19/T790M/C797S mutant using ATP-labelled peptide substrate by HTRF assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The new opportunities in medicinal chemistry of fourth-generation EGFR inhibitors to overcome C797S mutation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.50 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5172794 | — | — | 1 | 9.70 |
| CHEMBL5176129 | — | — | 1 | 9.70 |
| CHEMBL5187838 | — | — | 1 | 9.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5172794 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5176129 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5187838 | — | IC50 | = | 0.8 | nM | 9.10 |