Assay Detail
Functional
CHEMBL5215229
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Antagonist activity at Adrenergic alpha-1 receptor (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Therapeutic progression of quinazolines as targeted chemotherapeutic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.49 | 8.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 8.91 |
| CHEMBL188185 | BUNAZOSIN | 3.0 | 1 | 8.91 |
| CHEMBL709 | ALFUZOSIN | 4.0 | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | IC50 | = | 1.23 | nM | 8.91 |
| CHEMBL188185 | BUNAZOSIN | IC50 | = | 1.22 | nM | 8.91 |
| CHEMBL709 | ALFUZOSIN | IC50 | = | 23.0 | nM | 7.64 |